PhD Position in Developmental Biology / Cell Biology / Genetics / Functional Genomics / Evolution

Stellenmarkt für Doktoranden: Hier können Sie kostenlos Ihre Promotionsmöglichkeit anbieten oder Ihre Veranstaltung für Doktoranden ankündigen.
Bitte keine allgemeine Fragen oder Diskussionen!
Forumsregeln
Stellenmarkt für Doktoranden.
Stellenangebote für Doktoranden und Veranstaltungshinweise für Promovierende können Sie hier schnell, kostenlos und auf die Zielgruppe fokussiert einstellen. Die Nutzung des Forums ist für Anbieter und Leser kostenlos.
Bitte keine allgemeinen Diskussionen und keine gewerblichen "Kleinanzeigen".
Sämtliche externen Links im Forum werden zur Vermeidung von Mißbrauch mit dem nofollow-Attribut gekennzeichnet.

Stellenbewerber: Wenn Du Dich auf eine hier angekündigte Stelle bewirbst, nimm bitte auf die Veröffentlichung hier Bezug - das hilft allen Beteiligten. Dankeschön!
Als registrierter Benutzer kannst Du Dich über neue Beiträge in diesem Forum per Mail informieren lassen.
Antworten
klingler14
Neu hier
Beiträge: 1
Registriert: 16.08.2019, 21:22
Hat sich bedankt: 0
Danksagung erhalten: 0

PhD Position in Developmental Biology / Cell Biology / Genetics / Functional Genomics / Evolution

Beitrag von klingler14 » 16.08.2019, 21:51

PhD Project: Specification of leg segments during insect development

In this project, the candidate will analyze a number of leg genes we identified during a genome-wide RNAi screen in the flour beetle Tribolium (Nat Commun 2015; 6:7822) which include previously unknown components of this developmental pathway. Since many appendage genes are conserved among arthropods and even vertebrates, this work also has implications for the evolution of morphological diversity within arthropods, and macroevolution of vertebrate and arthropod bauplans.

Background: Although segmented legs are an important character of the largest animal phylum, the arthropods, it still is not known how these jointed legs are formed. Work in the fruit fly Drosophila has identified early active regionalizing leg genes (e.g. dac and Dll), as well as late acting genes specifying leg joints, but the regulatory steps in-between are not understood (for images see a PDF of this advertisement: https://faubox.rrze.uni-erlangen.de/dl/ ... nU/?inline.)

While appendages in Drosophila develop from imaginal discs deep within the larval body, in our model system Tribolium castaneum the legs develop during embryogenesis and can easily be monitored by live imaging. A multitude of genetic and molecular techniques are available in this beetle, including CRISPR, RNAi and transgenics, as well as genomic and imaging methods.

We seek a highly motivated individual with enthusiasm for animal development and genetics, who is interested in solving a patterning problem of similar fundamental importance as body segmentation in vertebrates and arthropods. The candidate should have experience in basic molecular methods. A background in cell biology, biochemistry, developmental biology, advanced imaging or computer modelling would be an advantage.

Applications including a cover letter stating your motivation, a brief summary of previous research experience, CV, Masters certificate (or equivalent) and contact information for two referees should be sent as single PDF document to Prof. Martin Klingler, martin.klingler@fau.de. Applications will be considered starting Sept. 1st until the position is filled. For additional information please contact me by email.

Antworten